Practitioners. Several questions emerged during the debate. Should GPs with specific interests be better paid than pure generalists? Or, as one GP said, is the expert generalist "gold", and therefore worth their weight in this said substance? Another issue concerns membership of Australia's only college for generalists. In other words, why should doctors who work on only one particular part of the body be accepted into the Royal.
The cost of pads decreased significantly as a result of treatment [Table 28]. The costs for the three months were then estimated over 5 years. The 5 year cost was discounted to 4.2124 years as previously discussed [chapter 3.8]: [trips to the unit x trip cost] [cost saved on pads month x 13 x 4.2124] + [clinician costs] + [drug costs month x 13 x 4.2124] + [administrative costs hr x hours of visit] + [investigation costs] + [lost time from work x trips to the unit]. The QALY was thence calculated by dividing the above cost by the [York change x 4.2124 x the estimated 5 year success rate percentage 50% ; ]. The only significant difference between the NCA and Urogynaecologist group was that the NCA's spent significantly longer time with their patients [Table 29] and leukeran.

DEFINITION OF A MAJOR PANDEMIC , Influenza virus causes outbreaks of influenza every winter season. These outbreaks are of variable intensity but usually affect between 530% of the population resulting in a highly variable degree of morbidity and some mortality which is virtually confined to elderly individuals, especially those with underlying medical conditions. , When significant antigenic variation occurs in the virus see Section III ; so that the population is largely susceptible, significantly greater epidemic activity occurs which is often global in extent, with varying intensity in different countries often depending on population immunity. These widespread epidemics of influenza are sometimes referred to as pandemics because of their global activity. , The major pandemics of influenza are, however, rare events but have dramatic and very major implications. These occur as a result of.
Surgeon General's Report next six months, thinking seriously about quitting in the next six months, planning to quit in the next month, actually trying to quit, and trying to remain abstinent. If relapse occurs, smokers return to an earlier stage in the model. It is hypothesized that smokers in the initial stages are less ready to quit and thus less likely to profit from traditional treatments see Orleans 1993 for a more detailed discussion ; . Some evidence supports the notion that smokers in earlier stages of change fare worse in smoking cessation than do smokers in later stages DiClemente et al. 1991; Kristeller et al. 1992; Ockene et al. 1992; Rohren et al. 1994 ; . The finding of interactions between treatment assignment and stage membership Prochaska et al. 1993 ; has led to the recommendation that clinical protocols for smoking cessation be based on stage assessments Abrams 1993; Orleans 1993; Velicer et al. 1993; Hughes 1994 ; . Evidence is not available, however, that linking motivational stage to a stage-appropriate strategy leads to better outcomes than do nontailored interventions of equal intensity see Prochaska et al. 1993; Fiore et al. 2000 ; , perhaps because motivation to change is more a continuum than a set of discrete states Lichtenstein et al. 1994 ; . Nonetheless, the stages-ofchange model has considerable theoretical and empirical appeal as a typology that is easy to use in day-to-day decision making Wiggins 1988 ; . Further refinement and clarification of this model, coupled with continued assessment of its relationship to smokers' probability of quitting, is a potentially fruitful research area. Negative Affect A negative affective reaction to quitting tobacco use Baker et al. 1987; Brandon 1994; Hall et al. 1994 ; may be an important predictor of relapse Shiffman 1982; Brandon et al. 1990; Piasecki et al. 1997 ; . As mentioned previously, depressed persons are less likely to quit smoking successfully than persons without a history of depression Glassman et al. 1988; Anda et al. 1990 ; , and depressed persons suffer an increase in symptoms after quitting Covey et al. 1990; Hall et al. 1991 ; . These related findings have special importance because the frequency of clinical depression among smokers may exceed that among nonsmokers Frederick et al. 1988; Hall et al. 1991; Brandon 1994 ; . The role of adverse psychological states--even mild conditions--in prolonging smoking and impeding cessation is an important avenue for further investigation. For example, depressed or otherwise affectively disturbed persons may require special interventions to succeed in smoking cessation; at least two studies have identified behavioral treatments that have boosted success rates among such persons Zelman et al. 1992; Hall et al. 1994 ; . As noted, antidepressants and anxiolytics have been proposed as smoking cessation aids and are undergoing clinical trials because of their ability to ameliorate negative affects. Sex-Specific Differences Some studies Pomerleau et al. 1991; Kenford et al. 1993; Swan et al. 1993 ; , but not all Derby et al. 1994; Whitlock et al. 1997; Gritz et al. 1998 ; , have suggested that women find it more difficult than men to quit smoking. The quit ratio the proportion of persons who have quit smoking out of those who ever smoked ; has increased at the same rate or at a faster rate among women than men in recent years Fiore et al. 1989; Giovino et al. 1994; Husten et al. 1996 ; . An extensive review of difference in nicotine effects between men and women Perkins et al. 1999 ; cites complex differences in psychological and biologic aspects in the maintenance of nicotine self-administration. Women may differ from men in the response to withdrawal, possibly mediated by menstrual cycle phase Perkins et al. 2000 ; , as well as a variety of nonnicotine effects Perkins et al. 1999 ; . For example, although the same treatments benefit both women and men, some treatments e.g., nicotine replacement therapies ; may be less efficacious in women Perkins 1996; Wetter et al. 1999; Fiore et al. 2000 ; . Other reviews of this phenomenon Fant et al. 1996; Christen and Christen 1998 ; confirm the need for further exploration of such differences. A further difference between men and women may be related to genetic factors, particularly differences by sex in the metabolism of nicotine Messina et al. 1997; Tyndale et al. 1999 ; . These studies have focused on differences in the roles of enzymes involved in the metabolism of nicotine to cotinine enzymes CYP2A6 and CYP2D6 ; . The considerable variability in nicotine metabolism appears to be due to variable expression of CYP2A6 Messina et al. 1997 ; and may play a role, as yet undefined, in gender response to therapeutic modalities. Other researchers, using studies of twins, have postulated that genetic factors may play a role in predicting which cigarette smokers progress to long-term addiction, an effect that may be stronger for men than for women Heath et al. 1998 ; . Withdrawal Symptoms The vast majority of smokers become physically dependent on nicotine, and these persons commonly and viramune.

ANTI-EMETOGENICS ANTIEMETIC ANTICHOLINERGIC DOPAMINERGIC MC DEL MC DEL MC DEL MC DEL MC DEL MC ANTIEMETIC - 5-HT3 RECEPTOR ANTAGONISTS SUBSTANCE P NEUROKININ MC MC DEL MC DEL MC DEL MC DEL MECLIZINE HCL TABS PHENERGAN SUPP PHENERGAN FORTIS SYRP PROMETHAZINE SUPP PROMETHAZINE TRANSDERM-SCOP PT72 EMEND MARINOL CAPS ZOFRAN SOLN * ZOFRAN TABS * ZOFRAN ODT TBDP * MC MC MC DEL MC ALOXI ANZEMET TABS CESAMET1 KYTRIL ONDANSETRON * See quantity limit table. 1. Approvals will require diagnosis of chemo-induced nausea vomiting and failed trials of all preferred antiemetics, including 5-HT3 class Zofran, Emend ; and Marinol. Preferred drugs must be tried and failed due to lack of efficacy or intolerable side effects before non-preferred drugs will be approved, unless an acceptable clinical exception is offered on the Prior Authorization form, such as the presence of a condition that prevents usage of the preferred drug or a significant potential drug interaction between another drug and the preferred drug s ; exists. * Zofran limits still apply as listed on the Zofran PA form for covered indications including chemotherapy, radiotherapy, post operative nausea & vomiting and hyperemesis gravidarum. Other medical indications will be approved or denied on a case by case basis. Hyperemesis and other medical indications approved are still subject to failure of multiple preferred antiemesis drugs. MC MC DEL MC DEL MC DEL MC ANTIVERT TABS PHENERGAN SOLN PHENERGAN TABS PROMETHEGAN SUPP TORECAN TABS Use PA Form # 20420 Preferred drugs must be tried and failed due to lack of efficacy or intolerable side effects before non-preferred drugs will be approved, unless an acceptable clinical exception is offered on the Prior Authorization form, such as the presence of a condition that prevents usage of the preferred drug or a significant potential drug interaction between another drug and the preferred drug s ; exists. 01911481 02181479 02216965 INHIBACE - 5mg TAB INHIBACE PLUS 5 12.5 INVIRASE - 200mg CAP KYTRIL - 1mg TAB KYTRIL - 2mg TAB KYTRIL INJECTION - 1mg ml MANERIX - 100mg TAB MANERIX - 150mg TAB MANERIX - 300mg TAB MEGALONE - 4mg ml MEGALONE - 200mg TAB MEGALONE - 400mg TAB NAPROSYN - 25mg ml NAPROSYN - 500mg SUP NAPROSYN - 125mg TAB NAPROSYN - 250mg TAB NAPROSYN - 375mg TAB NAPROSYN - 500mg TAB NAPROSYN E - 250mg TAB NAPROSYN E - 375mg TAB NAPROSYN E - 500mg TAB NAPROSYN SR - 750mg TAB NAPROSYN SR - 1000mg TAB NUTROPIN - 5mg VIAL NUTROPIN - 10mg VIAL NUTROPIN AQ - 5mg ml NUTROPIN AQ PEN - 5mg ml OSTAC - 400mg CAP PEGASYS - 180MCG SYRINGE PEGASYS - 180MCG VIAL PEGASYS RBV PEGASYS RBV PROTROPIN - 5mg VIAL PROTROPIN - 10mg VIAL PULMOZYME - 2.5mg AMPOULE RHINALAR - 0.25mg ml RITUXAN - 10mg ml ROCALTROL - 0.00025mg CAP ROCALTROL - 0.0005mg CAP ROCALTROL - 0.001mg ml ROCEPHIN - 250mg VIAL ROCEPHIN - 500mg VIAL ROCEPHIN - 1000mg VIAL ROCEPHIN - 2000mg VIAL ROCEPHIN - 10000mg VIAL ROCEPHIN ADD-VANTAGE 1000mg VIAL ROCEPHIN ADD-VANTAGE 2000mg VIAL ROFERON-A - 3000000UNIT VIAL ROFERON-A - 3000000UNIT VIAL cilazapril cilazapril hydrochlorothiazide saquinavir mesylate granisetron hydrochloride granisetron hydrochloride granisetron hydrochloride moclobemide moclobemide moclobemide fleroxacin fleroxacin fleroxacin naproxen naproxen naproxen naproxen naproxen naproxen naproxen naproxen naproxen naproxen naproxen somatropin somatropin somatropin somatropin clodronate disodium peginterferon alfa-2a peginterferon alfa-2a peginterferon alfa-2a + ribavirin peginterferon alfa-2a + ribavirin somatrem somatrem dornase alfa flunisolide rituximab calcitriol calcitriol calcitriol ceftriaxone disodium ceftriaxone disodium ceftriaxone disodium ceftriaxone disodium ceftriaxone disodium ceftriaxone disodium ceftriaxone disodium interferon alfa-2a interferon alfa-2a C09AA C09BA J05AE A04AA A04AA A04AA N06AG N06AG N06AG J01MA J01MA J01MA M01AE M01AE M01AE M01AE M01AE M01AE M01AE M01AE M01AE M01AE M01AE H01AC H01AC H01AC H01AC M05BA L03AB L03AB J05AB J05AB H01AC H01AC R05CB R01AD L01XC A11CC A11CC A11CC J01DA J01DA J01DA J01DA J01DA J01DA J01DA L03AB L03AB tablet tablet capsule tablet tablet injectable solution tablet tablet tablet injectable solution tablet tablet oral suspension suppository tablet tablet tablet tablet tablet tablet tablet sustained-release tablet sustained-release tablet powder for injectable solution powder for injectable solution injectable solution injectable solution capsule injectable solution injectable solution injectable solution + tablet injectable solution + tablet powder for injectable solution powder for injectable solution solution for inhalation nasal aerosol injectable solution capsule capsule oral solution powder for injectable solution powder for injectable solution powder for injectable solution powder for injectable solution powder for injectable solution powder for injectable solution powder for injectable solution powder for injectable solution injectable solution and oxytrol. Nausea and vomiting emesis ; affect about 70% of patients Can combat this with anti-emetic drugs e.g. Kyyril granisetron ; Neutropenia reduced white blood cell count which may increase risk of infection ; is a common chemotherapy induced effect Medication e.g. Neupogen filgrastim ; means treatment can proceed as scheduled and the risk of potentially lifethreatening infections is reduced.

INDEX OF DRUGS Kerlone g ; .20 Ketek, Pak 11 Ketoconazole 7, 43 Ketoprofen 35 Ketorolac Tromethamine 35, 63, 81, Ketotifen Fumarate 61 Kineret 71 Klaron g ; .38 Kutrase .53 Ku-Zyme .53 Kwell g ; .42 Kytr8l Oral, I.V .52 L Labetalol Hydrochloride 20, 86 Laccream Laclotion g ; .41 Lac-Hydrin g ; 41 Lacrisert 61 Lactic Acid 41 Lactulose 54 Lamictal 26 Lamictal Chew g ; .26 Lamisil g ; Lamisil Topical Soln . Lamivudine 10 Lamivudine And Zidovudine . Lamotrigine .26 Lanoxicaps 25 Lanoxin Pediatric 101 Lansoprazole 55, 99 Lansoprazole And Naproxen .35 Lanthanum Carbonate 44 Lantus .48 Lapatinib Ditosylate 17 Lariam g ; Laronidase .49 Lasix g ; .22 Lasix I.V .90 Latanoprost .65 Leflunomide 71 Lenalidomide 16 Lescol 23 Lescol XL .23 Letrozole 16 Leucovorin Calcium 15, 79, 89 Leucovorin Calcium 10, 15mg .15 Leucovorin Calcium 5, 25mg g ; 15 and topamax.

Your doctor or educator will work with you to decide what medication may work best for you. Your blood sugar results will help to see if your current medications are controlling your blood sugars. Key Words Adrenal glands A pair of endocrine glands located on the surface of the kidneys. The adrenal glands produce corticosteroid hormones such as cortisol, aldosterone, and the reproductive hormones. Arthritis Literally means joint inflammation, but is often used to indicate a group of more than 100 rheumatic diseases. These diseases affect not only the joints but also other connective tissues of the body, including important supporting structures, such as muscles, tendons, and ligaments, as well as the protective covering of internal organs. Analgesic A medication or treatment that relieves pain. Connective tissue The supporting framework of the body and its internal organs. Chronic disease An illness that lasts for a long time, often a lifetime. Cortisol A hormone produced by the adrenal cortex, important for normal carbohydrate metabolism and for a healthy response to stress. Fibrous capsule A tough wrapping of tendons and ligaments that surrounds the joint. Fibromyalgia A chronic syndrome that causes pain and stiffness throughout the connective tissues that support and and atrovent. Services and receive bedside teaching along with didactic teaching. Drs. Morris Levin and Rand Swenson enhanced the program with the development of a series of case-based videos portraying patients with a range of neurological diagnoses. The project was funded by an internal Department of Medicine Education Committee grant. The series was tailored to emphasize material essential to medical student training following the American Academy of Neurology guidelines. The success of the video series will be evaluated using student surveys and test results. Neurology faculty also participate in the Scientific Basis of Medicine series for second year medical students. Addresses of Schools of Pharmacy in Australia can be found by visiting the Links section at the APC's website at pharmacycouncil .au 9.3 Information on Examination Procedures Examinations are conducted under strict supervision. The APC, or a representative of the APC, reserves the right to expel any candidate during an examination if it reasonably concludes the candidate guilty of unsatisfactory behaviour or it is not satisfied with a candidate's performance in any other way. 9.4 Closing Dates for Applications to Sit Examinations The closing dates for the acceptance of applications for the Stage II Examination will generally be at least six weeks prior to the examination. Precise dates can be obtained from the APC Secretariat on 61 2 6247 or by sending an e-mail to apec pharmacycouncil .au. 9.5 Results of Stage II Examination Candidates will be advised in writing of their results as soon as practicable after the completion of the examination. Generally this will be about two weeks ; . Results will not be given by phone, fax or e-mail. 9.6 Number of Attempts A candidate who fails the Stage II Examination may attempt the Examination again at any subsequent scheduled session. However the Committee strongly recommends that unsuccessful candidates undertake remedial study and or an additional period of supervised practice hours before they attempt the Examination again. The APC may refuse a candidate admission to a Stage II Examination due to unsatisfactory progress or unprofessional behaviour at any time during the APC examination process, including the period of practical experience. The Committee shall be the sole judge of eligibility to attempt the Stage II Examination. 9.7 Validity Period Candidates have a five year period to complete the full APC examination process after successfully completing both papers of the Stage I Examination. This five year period commences from the date of successful completion of the Stage I Examination i.e when both papers have been passed ; . If the validity period expires before the candidate has completed the process, they will be required to re-commence the APC examination process. 9.8 Fees The appropriate fees, which are payable in advance can be found in the fee schedule on pharmacycouncil .au. These fees are subject to review and may be changed from time to time. NOTE: 9.9 Separate fees apply to the APC appeals and review process and combivent. Kwai garlic oral kwelcof oral kwell top kwikactin top kytril iv kytril oral email this page printer friendly bookmark this page sponsored health centers looking for energy to maximize your day.

Kytril 0.1mg dosing Id. at p. 2-3, listing the following medications: Serotonin Antagonists, Ondansetron Zofran ; , Granisetron Kyril ; , Tropisetron Navoban ; , Dolasetron, Phenothiazines, Prochlorperazine Compazine ; , Chlorpromazine Thorazine ; , Thiethylperazine Torecan ; , Perphenazine Trilafon ; , Promethazine Phenergan ; , Corticosteroids, Dexamethasone Decadron ; , Methylprednisolone Medrol ; , Anticholinergics, Scopolamine Trans Derm Scop ; , Butyrophenones, Droperidol Inapsine ; , Haloperidol Haldol ; , Domperidone Motilium ; , Benzodiazepines, Lorazepam Ativan ; , Alprazolam Xanax ; , Substituted Benzamides, Metoclopramide Reglan ; , Trimethobenzamide Tigan ; , Alizapride Plitican ; , Cisapride Propulsid ; , Antihistamines, Diphenhydramine Benedryl and citing: Brief of the Institute on Global Drug Policy of the Drug Free America Foundation; National Families in Action; Drug Watch International; Drug-free Kids: America's Challenge, et al., as Amici Curiae in Support of Petitioner 2001WL 30659 Jan. 10, 2001 ; , U.S. v. Oakland Cannabis Buyers' Cooperative, 121 S.Ct. 1711 2001 List reconfirmed by Dr. Eric Voth on May 14, 2006. Id. p. 3, citing: The MS Information Sourcebook, produced by the National MS Society. Last updated October 2005 Id., citing: Neurology 2002; 58: 1404-14O7, "Safety, tolerability, and efficacy of orally administered cannabinoids in MS, " J. Killestein, MD, E. L.J. Hoogervorst, MD, M. Reif, PhD, N. F. Kalkers, MD, A. C. van Loenen, PhD, P. G.M. Staats, MA, R. W. Gorter, MD PhD, B. M.J. Uitdehaag, MD PhD and C. H. Polman, MD PhD Id., citing: Testimony of David G. Evans, Esq., Executive Director, Drug Free Schools Coalition Before The Policy And Strategy Panel Of The Medical Society Of New Jersey, October 18, 2007 available from the Drug Free Schools Coalition request via e-mail to: drugfreesc aol ; Id., p. 13, citing: Cabral & Vasquez, Delta-9-Tetrahydrocannabinol suppresses macrophage extrinsic anti-herpes virus activity, Cannabis: Physiopathology, Epidemiology, Detection pp. 137-153 CRC Press 1993 "Immunological Changes Associated with Prolonged Marijuana Smoking" -American College of Allergy, Asthma and Immunology, 17 November 2004; "Marijuana Component Opens The Door For Virus That Causes Kaposi's Sarcoma" -Science Daily, 2 August 2007; "Immunological Changes Associated with Prolonged Marijuana Smoking" -American College of Allergy, Asthma and Immunology, 17 November 2004 Id., p. 19, citing: Brief of the Institute on Global Drug Policy of the Drug Free America Foundation; National Families in Action; Drug Watch International; Drug-free Kids: America's Challenge, et al., as Amici Curiae in Support of Petitioner 2001WL 30659 Jan. 10, 2001 ; , U.S. v. Oakland Cannabis Buyers' Cooperative, 121 S.Ct. 1711 2001 ; Id., p. 6, citing: Brief of the Institute on Global Drug Policy of the Drug Free America Foundation; National Families in Action; Drug Watch International; Drug-free Kids: America's Challenge, et al., as Amici Curiae in Support of Petitioner 2001WL 30659 Jan. 10, 2001 ; , U.S. v. Oakland Cannabis Buyers' Cooperative, 121 S.Ct. 1711 2001 ; Id. Id., p. 7. Id., citing: Testimony Of David G. Evans, Esq., Executive Director, Drug Free Schools Coalition Before The Policy And Strategy Panel Of The Medical Society Of New Jersey October 18, 2007 available from the Drug Free Schools Coalition request via e-mail to: drugfreesc aol ; Id. at 7-8, citing and synthroid. CI to beta blockers from HEDIS. ICD9 codes are for insulin dependent diabetes, ashtma, heart block 1 degree, sinus braycardia, heart failure, left ventricular dysfunction, COPD. GASTROINTESTINAL AGENTS DRUGS TO TREAT BOWEL, INTESTINE OR STOMACH CONDITIONS 5-HT3 Receptor Antagonists Nausea and Vomiting Prevention Drugs 4 Aloxi 3 Anzemet Solution ; 4 Anzemet Tablet ; Kytril 0.1 mg ml Solution, 1 4 mg ml Solution ; Kytril 2 mg 10ml Oral 4 Solution, Tablet ; Ondansetron HCl 2 mg 3 ml Solution, 32 mg 50ml Solution ; Ondansetron HCl 4 mg 5ml 3 Oral Solution, Tablet ; 3 Ondansetron ODT Antidiarrhea Agents 3 Diphenoxylate Atropine 3 Lofene 3 Lonox 1 Loperamide HCl 3 Motofen 3 Opium Tincture 1 Paregoric and detrol and Cheap kytril.

Kytril therapy Prognostic significance. All subjects were 13 years of age or younger at onset and were followed for a minimum of three years. Follow-up included face-to-face interviews and corroborative information gathered from rela. [1] Incropera, Frank P. and David P. DeWitt. Fundamentals of Heat and Mass Transfer: 5th Edition. 2002. John Wiley & Sons. R.R. Donnelley & Sons Company. United States. p. 8 [2] Moran, Michael J. and Howard N. Shapiro Fundamentals of Engineering Thermodynamics: 5th Edition. 2004. John Wiley & Sons. Von Hoffman Corporation. United States. p. 760 [3] ASHRAE Handbook. American Society of Heating, Refrigerating and Air-Conditioning Engineers. 11 4 2005. : ashrae and diamox. 2. Influenza Hospitalizations The Kaiser surveillance system will capture trends in influenza hospitalizations. In addition, we may use the countywide EM Systems to track Emergency Room volume, bed types and availability. SCCPHD may also institute individual case reporting or batch reporting of influenza hospitalizations Tool 13; Tool 14 ; . Depending on resources, SCCPHD may conduct periodic studies at select hospitals to define the populations demographics, risk factors, outcomes ; infected with influenza or at greatest risk of complications. 3. Influenza Deaths It will be necessary to track influenza deaths in both hospitalized and non-hospitalized patients to calculate the case-fatality rate caused by the virus and to monitor morgue capacity and need for additional resources. It is likely that healthcare providers will be required to report influenza deaths among hospitalized patients. SCCPHD may also request influenza death reports from Influenza Care Centers. We will also continue to review death certificates for influenza-associated illnesses, which will act as a check on healthcare provider reported deaths. 4. Reporting and Data Collection a. SCCPHD will generate data reports for its own use, including decisions on when to implement more austere triage measures at area hospitals, when to collect viral isolates from patients, when to implement social distancing strategies and which ones, and potentially decisions about changes in vaccine or antiviral priority groups. SCCPHD anticipates that CDHS and CDC will also require some reporting to them, but we have not received clear instructions on these requirements to date.

Included in the Roche Pharmaceuticals business segment are intangible assets with a carrying value of 393 million Swiss francs and a remaining amortisation period of 1-2 years that relate to the purchase by the Group of the global rights to Kytril granisetron ; . The Diagnostics business segment includes intangible assets with a carrying value of 1, 744 million Swiss francs and a remaining amortisation period of 11 years that relate to the acquisition of Corange Boehringer Mannheim and intangible assets with a carrying value of 567 million Swiss francs and a remaining amortisation period of 10 years that relate to the acquisition of Igen. Intangible assets that are not yet available for use, which mostly arise from the Group's in-licensing arrangements, total 778 million Swiss francs. Of this total, 632 million Swiss francs relate to the Roche Pharmaceuticals business segment. The Group currently has no internally generated intangible assets from development as the criteria for the recognition as an asset are not met. Impairment charges arise from changes in the estimates of the future cash flows expected to result from the use of the asset and its eventual disposal. Factors such as the presence or absence of competition, technical obsolescence or lower than anticipated sales for products with capitalised rights could result in shortened useful lives or impairment. In the second half of 2006 the Group recorded impairment charges of 184 million Swiss francs relating to intangible assets in the Diagnostics Division. These followed the regular updating of the division's business plans and technology assessments in the second half of 2006, which indicated anticipated recoverable amounts that were below the current carrying values for certain assets. These mainly concern certain of the intangible assets recorded following the Disetronic acquisition in 2003. These assets were written down to their recoverable amount, based on a value in use calculation using a discount rate of 10.0%. Additionally the remaining useful life of these assets was reassessed and has been reduced from 6.3 years to 3 years, effective 31 December 2006. Consequent to these matters, the Group expects that the 2007 amortisation charge for intangible assets in the Diagnostics Division will be approximately 20 million Swiss francs lower than it would otherwise have been. In the Roche Pharmaceuticals business segment an impairment charge of 13 million Swiss francs was recorded in the second half of 2006, which relates to a decision to terminate development of one compound with an alliance partner. The asset concerned, which was not yet being amortised, was fully written-down by this charge.

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